The central theme of our research is the integration of functional genomics and computational methods to elucidate the molecular mechanisms of disease and to identify potential therapeutic targets. We develop and apply computational methods to leverage the depth and dimensionality of omics data derived from a range of molecular levels, for example transcript, microRNA, genomic structure, and protein. The methods are typically focused on the characterization of cellular pathways and signaling events involved in disease progression and pathology. We are engaged in ongoing collaborative studies associated with a variety of cancers, tuberous sclerosis, and asthma.
My research also includes the development of computational methods for protein structure analysis and protein engineering. Projects include software for the design of novel disulfide bonds in proteins (Disulfide by Design). Disulfide engineering has been effectively used to increase the stability of proteins and to assist investigations of protein dynamics and interactions.