Papers that Cite Disulfide by Design

Version 1.2
© Wayne State University, All Rights Reserved
Version Release Date: Sep. 16, 2003




Gosein, V., Miller, G.J. Conformational Stability of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase (IPK1) Dictates Its Substrate Selectivity. J Biol Chem. 2013 Dec 27;288(52):36788-95. Epub 2013 Oct 28. DOI: 10.1074/jbc.M113.512731

Geng, Y., Bush, M., Mosyak, L., Wang, F., Fan, Q.R. Structural mechanism of ligand activation in human GABAB receptor. Nature. 2013 Dec 4. [Epub ahead of print]. DOI: 10.1038/nature12725 PMID: 24305054

Ding, H., Gao, F., Liu, D., Li, Z., Xu, X., Wu, M., Zhao, Y. Significant improvement of thermal stability of glucose 1-dehydrogenase by introducing disulfide bonds at the tetramer interface. Enzyme Microb Technol. 2013 Dec 10;53(6-7):365-72. Epub 2013 Aug 16. DOI: 10.1016/j.enzmictec.2013.08.001 PMID: 24315638

Ziarek, J.J., Getschman, A.E., Butler, S.J., Taleski, D., Stephens, B., Kufareva, I., Handel, T.M., Payne ,R.J., Volkman, B.F. Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol. 2013 Sep 20;8(9):1955-63. Epub 2013 Jun 26. DOI: 10.1021/cb400274z PMID: 23802178

Housden, N.G., Hopper, J.T., Lukoyanova, N., Rodriguez-Larrea, D., Wojdyla, J.A., Klein, A., Kaminska, R., Bayley, H., Saibil, H.R., Robinson, C.V., Kleanthous, C. Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF. Science. 2013 Jun 28;340(6140):1570-4. DOI: 10.1126/science.1237864

Farrance, O.E., Hann, E., Kaminska, R., Housden, N.G., Derrington, S.R., Kleanthous, C., Radford, S.E., Brockwell, D.J. A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein. PLoS Biol. 2013 Feb 19; 11(2): e1001489. DOI: 10.1371/journal.pbio.1001489

McConnell, A.D., Spasojevich, V., Macomber, J.L., Krapf, I.P., Chen, A., Sheffer, J.C., Berkebile, A., Horlick, R.A., Neben, S., King, D.J., Bowers, P.M. An integrated approach to extreme thermostabilization and affinity maturation of an antibody. Protein Engineering, Design and Selection. 2013 Feb;26(2):151-163. PMID: 23173178


Hoffmann, A., Becker, A.H., Zachmann-Brand, B., Deuerling, E., Bukau, B., Kramer, G. Concerted action of the ribosome and the associated chaperone trigger factor confines nascent polypeptide folding. Molecular Cell. 2012 Oct 12;48(1):63-74. DOI: 10.1016/j.molcel.2012.07.018 PMID: 22921937

Doreleijers, J.F., Sousa da Silva, A.W., Krieger, E., Nabuurs, S.B., Spronk, C.A., Stevens, T.J., Vranken, W.F., Vriend, G., Vuister, G.W. CING: an integrated residue-based structure validation program suite.. Journal of Biomolecular NMR. 2012 Nov;54(3):267-83. DOI: 10.1007/s10858-012-9669-7 PMID: 22986687

Saman Hosseinkhani, Mahboobeh Nazari and Leila Hassani. Step-wise addition of disulfide bridge in firefly luciferase controls color shift through a flexible loop: A thermodynamic perspective. Photochemical & Photobiological Sciences. 2012 Sep 04. DOI: 10.1039/C2PP25140J

Kim, D.Y., Kandalaft, H., Ding, W., Ryan, S., van Faassen, H., Hirama, T., Foote, S.J., Mackenzie, R., Tanha, J. Disulfide linkage engineering for improving biophysical properties of human VH domains. Protein Engineering, Design & Selection. 2012 Aug 30. [Epub ahead of print]. PMID: 22942392

Hoffmann, A., Becker, A.H., Zachmann-Brand, B., Deuerling, E., Bukau, B., Kramer, G. Concerted Action of the Ribosome and the Associated Chaperone Trigger Factor Confines Nascent Polypeptide Folding. Molecular Cell. 2012 Aug 22. [Epub ahead of print]. PMID: 22921937

Glynn, S.E., Nager, A.R., Baker, T.A., Sauer, R.T. Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine. Nature Structural and Molecular Biology. 2012 May 6; 19(6):616-622. PMID: 22562135

Le, Q.A.T., Joo, J.C., Yoo, Y.J., Kim, Y.H. Development of thermostable Candida antarctica lipase B through novel in silico design of disulfide bridge. Biotechnology and Bioengineering. 2012 Apr; 109(4):867-876. PMID: 22095554

Deaconescu, A.M., Sevostyanova, A., Artsimovitch, I., Grigorieff, N. Nucleotide excision repair (NER) machinery recruitment by the transcription-repair coupling factor involves unmasking of a conserved intramolecular interface. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3353-8. PMID: 22331906
[see Supplemental Information]

Badieyan, S., Bevan, D.R., Zhang, C. Study and design of stability in GH5 cellulases. Biotechnology and Bioengineering. 2012 Jan; 109(1):31-44. PMID: 21809329


Härd, T. Protein engineering to stabilize soluble amyloid β-protein aggregates for structural and functional studies. FEBS Journal. 2011 Oct; 278(20):3884-3892. PMID: 21824290

Nazari, M., Hosseinkhani, S. Design of disulfide bridge as an alternative mechanism for color shift in firefly luciferase and development of secreted luciferase. Photochemical and Photobiological Sciences. 2011 Jul; 10(7):1203-1215. PMID: 21494742

Compton, J.R., Legler, P.M., Clingan, B.V., Olson, M.A., Millard, C.B. Introduction of a disulfide bond leads to stabilization and crystallization of a ricin immunogen. Proteins: Structure, Function and Bioinformatics. 2011 Apr; 79(4):1048-1060. PMID: 21387408

Huang, C.-C., Orban, T., Jastrzebska, B., Palczewski, K., Tesmer, J.J.G. Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry. 2011 Mar 22; 50(11):1940-1949. PMID: 21265573


Muskotál A, Seregélyes C, Sebestyén A, Vonderviszt F. Structural basis for stabilization of the hypervariable D3 domain of Salmonella flagellin upon filament formation. J Mol Biol. 2010 Nov 5;403(4):607-15. Epub 2010 Sep 22. PMID: 20868693

Han L, Monné M, Okumura H, Schwend T, Cherry AL, Flot D, Matsuda T, Jovine L. Insights into egg coat assembly and egg-sperm interaction from the X-ray structure of full-length ZP3. Cell. . 2010 Oct 29;143(3):404-15. Epub 2010 Oct 21. PMID: 20970175
[see Supplemental Information]

Logan T, Clark L, Ray SS. Engineered disulfide bonds restore chaperone-like function of DJ-1 mutants linked to familial Parkinson's disease. Biochemistry. 2010 Jul 13;49(27):5624-33. PMID: 20527929

Xingzhou Chen, Shunqing Xu, Maosheng Zhu, Luosheng Cui, Hui Zhu, Yunxiang Liang, Zhongming Zhang Site-directed mutagenesis of an Aspergillus niger xylanase B and its expression, purification and enzymatic characterization in Pichia pastoris. Process Biochemistry. Volume 45, Issue 1, January 2010, Pages 75-80.
DOI: 10.1016/j.procbio.2009.08.009


Wu SC, Ng KK, Wong SL. Engineering monomeric streptavidin and its ligands with infinite affinity in binding but reversibility in interaction. Proteins. 2009 Nov 1;77(2):404-12. PMID: 19425108

Han ZL, Han SY, Zheng SP, Lin Y. Enhancing thermostability of a Rhizomucor miehei lipase by engineering a disulfide bond and displaying on the yeast cell surface. Appl Microbiol Biotechnol. 2009 Nov;85(1):117-26. Epub 2009 Jun 17. PMID: 19533118

Zhang H, Kenaan C, Hamdane D, Hoa GH, Hollenberg PF. Effect of conformational dynamics on substrate recognition and specificity as probed by the introduction of a de novo disulfide bond into cytochrome P450 2B1. J Biol Chem. 2009 Sep 18;284(38):25678-86. Epub 2009 Jul 15. PMID: 19605359

Bornschlögl T, Anstrom DM, Mey E, Dzubiella J, Rief M, Forest KT. Tightening the knot in phytochrome by single-molecule atomic force microscopy. Biophys J. 2009 Feb 18;96(4):1508-14. PMID: 19217867

Jankun J, Aleem AM, Selman SH, Basrur V, Skrzypczak-Jankun E. VLHL plasminogen activator inhibitor spontaneously reactivates from the latent to active form. Int J Mol Med. 2009 Jan;23(1):57-63. PMID: 19082507


Mateo R, Luna E, Rincón V, Mateu MG. Engineering viable foot-and-mouth disease viruses with increased thermostability as a step in the development of improved vaccines. J Virol. 2008 Dec;82(24):12232-40. Epub 2008 Oct 1. PMID: 18829763

Guo Q, Jureller JE, Warren JT, Solomaha E, Florián J, Tang WJ. Protein-protein docking and analysis reveal that two homologous bacterialadenylyl cyclase toxins interact with calmodulin differently. J Biol Chem. 2008 Aug 29;283(35):23836-45. PMID: 18583346

Seeger MA, von Ballmoos C, Eicher T, Brandstätter L, Verrey F, Diederichs K, Pos KM. Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB. Nat Struct Mol Biol. 2008 Feb;15(2):199-205. Epub 2008 Jan 27. PMID: 18223659


Sjoelund V and Kaltashov IA. Transporter-to-Trap Conversion: a Disulfide Bond Formation in Cellular Retinoic Acid Binding Protein I Mutant Triggered by Retinoic Acid Binding Irreversibly Locks the Ligand Inside the Protein. Biochemistry. 2007 Nov 20;46(46):13382-90. PMID: 17958379

Dubey VK, Lee J, Somasundaram T, Blaber S, Blaber M. Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus β-strand interactions. J Mol Biol. 2007 Aug 3;371(1):256-68. Epub 2007 May 31. PMID: 17570396

Asgeirsson B, Adalbjörnsson BV, Gylfason GA. Engineered disulfide bonds increase active-site local stability and reduce catalytic activity of a cold-adapted alkaline phosphatase. Biochim Biophys Acta. 2007 Jun;1774(6):679-87. Epub 2007 Apr 5. PMID: 17493882

Zloh M, Shaunak S, Balan S, Brocchini S. Identification and insertion of 3-carbon bridges in protein disulfide bonds: a computational approach. Nat Protoc. 2007;2(5):1070-83. PMID: 17545999


Brocchini S, Balan S, Godwin A, Choi JW, Zloh M, Shaunak S. PEGylation of native disulfide bonds in proteins. Nature Protocols. 2006;1(5):2241-52. PMID: 17406463

Shen Y, Joachimiak A, Rosner MR, Tang WJ. Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism. Nature. 2006 Oct 19;443(7113):870-4. Epub 2006 Oct 11. PMID: 17051221

Pellequer JL, Chen SW. Multi-template approach to modeling engineered disulfide bonds. Proteins. 2006 Oct 1;65(1):192-202. PMID: 16807887

Bhushan S, Johnson KA, Eneqvist T, Glaser E. Proteolytic mechanism of a novel mitochondrial and chloroplastic PreP peptidasome. Biol Chem. 2006 Aug;387(8):1087-90. PMID: 16895479

Meinhold D, Beach M, Shao Y, Osuna R, Colon W. The location of an engineered inter-subunit disulfide bond in factor for inversion stimulation (FIS) affects the denaturation pathway and cooperativity. Biochemistry. 2006 Aug 15;45(32):9767-77. PMID: 16893178

Cui C, Zhao W, Chen J, Wang J, Li Q. Elimination of in vivo cleavage between target protein and intein in the intein-mediated protein purification systems. Protein Expr Purif. 2006 Nov;50(1):74-81. Epub 2006 Jun 15. PMID: 16884922

Jeong MY, Kim S, Yun CW, Choi YJ, Cho SG. Engineering a de novo internal disulfide bridge to improve the thermal stability of xylanase from Bacillus stearothermophilus No. 236. J Biotechnol. 2006 Jul 16. PMID: 16919348

Jai Kartik V, Lavanya T, Guruprasad K. Analysis of disulphide bond connectivity patterns in protein tertiary structure. Int J Biol Macromol. 2006 May 30;38(3-5):174-9. Epub 2006 Apr 3. PMID: 16580722

Laptenko O, Kim SS, Lee J, Starodubtseva M, Cava F, Berenguer J, Kong XP,Borukhov S. pH-dependent conformational switch activates the inhibitor of transcription elongation. EMBO J. 2006 May 17;25(10):2131-41. Epub 2006 Apr 20. PMID: 16628221

Johnson KA, Bhushan S, Stahl A, Hallberg BM, Frohn A, Glaser E, Eneqvist T. The closed structure of presequence protease PreP forms a unique 10,000 Å3 chamber for proteolysis. EMBO J. 2006 May 3;25(9):1977-86. Epub 2006 Apr 6. PMID: 16601675


Ma K, Temiakov D, Anikin M, McAllister WT. Probing conformational changes in T7 RNA polymerase during initiation and termination by using engineered disulfide linkages. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17612-7. Epub 2005 Nov 21. PMID: 16301518

Karlsson M, Martensson LG, Karlsson C, Carlsson U. Denaturant-assisted formation of a stabilizing disulfide bridge from engineered cysteines in nonideal conformations. Biochemistry. 2005 Mar 8;44(9):3487-93. PMID: 15736958


Anthony LC, Burgess RR. Conformational flexibility in sigma70 region 2 during transcription initiation. J Biol Chem. 2002 Nov 29;277(48):46433-41. Epub 2002 Sep 30. PMID: 12359719

Anthony LC, Dombkowski AA, Burgess RR. Using disulfide bond engineering to study conformational changes in the β'260-309 coiled-coil region of Escherichia coli RNA polymerase during σ70 binding. J Bacteriol. 2002 May;184(10):2634-41. PMID: 11976292